The association between PON1 gene polymorphisms (Q192R and L55M) and nephrotic syndrome in Iraqi children

Background: The role of paraoxonase 1 enzyme (PON1) and its single nucleotide polymorphisms (SNPs) in children with nephrotic syndrome (NS) has been reported previously different ethnic racial groups divergent results. human PON1 gene contains two coding region leading to isoforms. Objectives: aim the present study was find out association between (Q192R L55M) their relation serum activity as well lipid profile tests (total cholesterol, TC; triglycerides, TG; high-density lipoprotein HDL-c; low-density LDL-c) NS. Methods: This included a total 80 participants (40 NS age group 2-14 years 40 sex-matched healthy controls). were measured samples all participants. genotype determined by PCR-restriction fragment length polymorphism (PCR-RFLP) for both alleles (192 55) SNPs. Results: Our findings showed that mean levels (TC, TG, significantly increased patients when compared controls (p<0.05), while HDL-c concentration decreased than controls. Also, had lower concentrations regardless Q192R L55M polymorphisms. Moreover, homozygous RR SNP 192 MM 55 frequent Conclusions: results support presence higher